To verify that miR-552-5p can inhibit PTEN/TOB1 expression to accelerate tumor progression, plasmids to overexpress PTEN (oe-PTEN) or a negative control (oe-NC) were stably transfected into SGC-7901 and AGS cells expressing Lv-miR-552-5p. This evidence concerns the gene PTEN and neoplasm.