Knockdown of cellular DAPK1 expression was associated with a significant decrease of intrinsic cell death in topotecan-treated cells, as indicated by the reduced caspase-3/7 activities and PARP cleavage, suggesting an important role of DAPK1 in the death of cervical cancer cells induced by topotecan (Fig. 6C). The gene discussed is DAPK1; the disease is cervical carcinoma.