Additional mechanisms for the silencing of DAPK1 function include allelic loss in the region of the DAPK gene in non-small cell lung cancer cell lines 50 and post-translational mechanisms, such as the hyperphosphorylation of the DAPK protein in colon cancer cell lines and primary tissues with high SRC activity 36. This evidence concerns the gene DAPK1 and malignant colon neoplasm.