Additional mechanisms for the silencing of DAPK1 function include allelic loss in the region of the DAPK gene in non-small cell lung cancer cell lines 50 and post-translational mechanisms, such as the hyperphosphorylation of the DAPK protein in colon cancer cell lines and primary tissues with high SRC activity 36. The gene discussed is SRC; the disease is malignant colon neoplasm.