NFKB1 and intervertebral disk degenerative disorder: In vitro experiments showed that quercetin ameliorated the progression of IDD by suppressing the expression of senescence associated secreted phenotype factors and improving the senescence phenotype of NP cells via the Nrf2/NF-κB axis [49]; luteolin, a natural flavonoid, has anti-inflammatory and anticatabolic effects [50]; kaempferol has been reported to regulate osteogenesis/adipogenesis balance and inhibit inflammation in bone mesenchymal stem cells to slow the progression of IDD [51].