Through the target interaction network, we screened out 15 Radix Salviae antihuman GBM key targets (MMP2, MMP1, MET, NF-κBI, AMMP9, PTGS2, IFNG, ICAM1, IL-4, PPARG, HMOX1, IL-6, ERBB2, RELA, and FOS), the condition being node ≥100. This evidence concerns the gene MMP2 and glioblastoma.