The molecular signaling pathways of hub targets in Radix Salviae against human GBM were intently interrelated with hepatitis B, Kaposi sarcoma-associated herpesvirus infection, lipid and atherosclerosis, PI3K-Akt signaling pathway, human cytomegalovirus (HCMV) infection, Epstein–Barr virus infection, proteoglycans in cancer, prostate cancer, endocrine resistance, IL-17 signaling pathway, measles, hepatitis c, colorectal cancer, small cell lung cancer, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, TNF signaling pathway, and so on (Figure 5). The gene discussed is RENBP; the disease is atherosclerosis.