In intervertebral disc degeneration, circRNA-CIDN was revealed to promote the homeostatic of extracellular matrix through miRNA-34a-5p/SIRT1 axis and inhibit apoptosis, providing a new perspective for the study of the pathogenesis of compression intervertebral disc degeneration [21]. This evidence concerns the gene SIRT1 and Intervertebral disk degeneration.