Another branch derived from subclone3 is characterized by the mutations in GATA1, RBFOX1, TRRAP, EYS, and ZNF521. It is noted that GATA1 is reported as an important gene to promote CRC migration (Yu et al., 2019), and RBFOX1 deletion occurs with high prevalence in CRC patients (Sengupta et al., 2013). The gene discussed is ZNF521; the disease is colorectal carcinoma.