While this particular SCN5A variant has a relative high MAF (e.g. MAF in GnomAD European population 0.2%) and its pathogenicity has recently has been debated (Risgaard et al., 2013; Ghouse et al., 2017), it cannot be excluded that it may have contributed to arrhythmia in this individual. This evidence concerns the gene SCN5A and Arrhythmia.