In the ROHet of 39.2–43.05 Mb on SSC16, the Aggrecan (ACAN) gene is known to affect cartilage development, and homozygous and compound heterozygous of the four ACAN alleles cause chondrodysplastic dwarfism in Miniature horses (Eberth et al., 2018). Here, ACAN is linked to Severe short stature.