ARHGEF12 and acute lymphoblastic leukemia: A study conducted by Xie and group reported that GATA-1 motif flanking 5 kb upstream ARHGEF12 was impaired due to the CC to TT SNPs in hematopoietic cells of ALL patients suggesting that GATA-1 transcriptional activation of ARHGEF12 is crucial in driving erythrogenesis in which ALL patients lacked.