FLCN and Friedreich ataxia: Moreover, the mutation of the tumor suppressor gene SLX4 was recently shown to be associated with the early-onset of CRC in the population of Kazakhstan (Zhunussova et al., 2019).Among these germline variants, mutations in SLX4, FANCD2, and FLCN are associated with FA pathway alteration (provided by RefSeq, NCBI).