TSC2 and intestinal cancer: A total of 17 gene mutations such as TCF7L2, KMT2D, PRKDC, NOTCH1, KMT2C, ERBB3, and TSC2, and others were more common in patients with bowel cancer with P/LP germline mutations; strikingly, SMAD4 exhibited the opposite prevalence and its mutation frequency in the Non-P group was significantly higher than that in the P/LP group (Figure 3A).