FANCA and Friedreich ataxia: Although the present study detected germline mutations in these DDR pathways, a higher number of genes were identified which were involved in the FA pathway compared with the previous studies, such as FANCD2, FANCA, FANCG, FANCL, and SLX4. The identification of a wider causative mutation in bowel cancer has implications that can apply to genetic counseling practices that are of vital importance for the family under investigation (Wells and Wise, 2017).