In addition to commonly mutated genes such as APC, ATM, and LS-related genes that have been previously reported (Bernstein and Concannon, 2017; Snowsill et al., 2017; Aghabozorgi et al., 2019), the current analysis further revealed significantly higher rates of FANCD2 and RAD51D mutations in bowel cancer germline mutation carriers than those of the general population, suggesting that FANCD2 and RAD51D can be considered as bowel cancer-susceptibility genes. The gene discussed is APC; the disease is intestinal cancer.