TP53 and nasal cavity polyp: The exosome proteome revealed that the human nasal epithelium-derived secreted exosomes from Chronic rhinitis sinusitis with nasal polyps (CRSwNP) patients contain proteins that affect cell proliferation pathways and are involved in epithelial remodeling, mainly via p53-mediated pathways and other pathways, which may lead to remodeling of the sinus mucosa (40).