Figure 6A shows the number of splenic CD8+IL-10+ increased significantly in animals pretreated with alphatoc. In addition, the number of splenic myeloid suppressor cells able to produce IL-10 (CD11b+GR-1+IL-10+) also rose on day 60th post-infection (Figure 6B). The percentages (not shown) and numbers of CD4+IL-10+ T cells were not different from infected vehicle pretreated mice (Figure 6A). Here, ITGAM is linked to infection.