CGAS and Flavivirus Infections: In a typical flavivirus infection process, viral RNA could be identified by a variety of PRRs, such as TLRs (20), RLRs (21, 22), cyclic GMP-AMP synthase (cGAS) and NLRs (23), which ultimately produce pro-inflammatory cytokines and induce antiviral status (Figure 3 and Table 1).