Myeloid-derived suppressor cells and macrophages recruited to the tumor microenvironment from the bone marrow by tumor cells and Tregs are also potent suppressors of anti-tumor immunity, when they are converted to an immunosuppressive phenotype by cytokines such as IL-10, which was found to increase perioperatively in our study and TGF-β (36) which are secreted by tumor tissue as well as other immune and stromal cells to promote recruitment and suppression of many immune cell types (37). The gene discussed is IL10; the disease is neoplasm.