Low-dose (0.1 g/kg) IgG glycoforms [(G2)2, (S2G2)2, (S2G2F)2, native] and high-dose (1 g/kg) native IgG as positive control were administered to the mice, and the group receiving the (G2)2 glycoform had the lowest arthritis score and serum interleukin-6 levels among the groups (Supplementary Figure 3). This evidence concerns the gene IL6 and arthritic joint disease.