In non-small cell lung cancer(NSCLC), tumor-derived exosomes(TDEs) polarize macrophages to an immunosuppressive phenotype that increases programmed death ligand-1 expression through NF-kB-dependent, glycolysis-dominated metabolic reprogramming, triggering the formation of pre-metastatic niche (58). Here, NFKB1 is linked to non-small cell lung carcinoma.