A single impact applied to the lumbar disc without causing structural damage to the lumbar spine also triggered significant upregulation of Piezo1, NLRP3 inflammatory vesicles, catabolic (MMP-9, MMP-13) and pro-inflammatory gene (IL-1β) expression and induced disc degeneration (IDD). The gene discussed is NLRP3; the disease is intervertebral disk degenerative disorder.