Most notable of the latter examples are the reports that anti-SSA/Ro60 antibodies cross react with the L-type calcium channel as a potential cause of neonatal Lupus (also known as congenital heart block) (31–33) and reports that certain anti-Ro52 antibodies cross-react with the hERG channel to elicit long QT syndrome (LQTS) (34–36). The gene discussed is TRIM21; the disease is congenital heart block.