In addition, elevated plasma Hsp90 was weakly associated with increased systemic levels of several key pro-inflammatory and pro-angiogenic cytokines/chemokines implicated in the pathogenesis of IIM, e.g., IL-1β, IL-6, IL-8, IL-17, IFN-γ, CXCL10, CCL2-4, VEGF, and PDGF (1–3, 35–42). This evidence concerns the gene IL1B and acquired idiopathic inflammatory myopathy.