Previous studies have demonstrated that caspase-1 activation and subsequent cleavage of GSDMD exert a crucial effect on pyroptosis and neuroinflammation in central nervous system (CNS) diseases such as cerebral ischemia and Alzheimer’s disease, and inhibiting Caspase-1 activation could mitigate brain injury (15–18). The gene discussed is CASP1; the disease is Alzheimer disease.