In contrast to previous studies that showed that Mcpt4-/- mice exhibited increased basal intestinal barrier integrity relative to Mcpt4+/+ mice (12), we observed an infection-associated decrease in intestinal barrier integrity in Mcpt4-/- mice (Figure 1B) and altered ileal E-cadherin staining (Figures 3C, D) that was similar to a pattern associated with increased enteric bacterial translocation in another mouse model (21). The gene discussed is CDH1; the disease is infection.