Regarding this pathology, Crabtree et al. (99) have described that an increase of HLA-G induced in an animal model of experimental autoimmune uveitis (both soluble and membrane-bound), reduces the severity of the pathology in these mice, thus reiterating the benefit of the tolerogenic role of the HLA-G molecule in autoimmune/inflammatory diseases. The gene discussed is HLA-G; the disease is autoimmune uveitis.