MT-ND4 and Kawasaki disease: We found that patients with acute Kawasaki disease had statistically significant higher levels of ND1, ND4, and COX1 mitochondrial DNA when compared to healthy controls (relative gene expression KD vs. HC: 1.69 ± 026 vs. 1 ± 0.17, 1.56 ± 0.25 vs. 1 ± 0.17, 1.58 ± 0.25 vs. 1 ± 0.18, p = 0.016, 0.047, 0.042 for ND1, ND4, and COX1, respectively) and febrile controls (relative gene expression KD vs. FC: 1.69 ± 0.26 vs. 1.06 ± 0.14, 1.56 ± 0.25 vs. 1.02 ± 0.15, 1.58 ± 0.25 vs. 1.11 ± 0.15, p = 0.028, 0.043, 0.095 for ND1, ND4, and COX1, respectively) (Figure 1).