In this study, from the fresh perspective of CIC, we identified ten prognosis-related genes (SLC25A27, ALB, CDKN3, TUBB3, AK5, DRD5, PLP1, PTGS2, OPCML, GUCY2C) that could classify PCA patients undergoing radical prostatectomy in the TCGA database into two groups and first provided a novel nomogram to predict progression for such patients. Here, PTGS2 is linked to posterior cortical atrophy.