In the research on SARS, it was found that HLA-B*46:01 and HLA-DRB1*12:02 were related to the development of SARS (31, 32), and HLA-Cw*08:01 was a susceptibility gene for SARS-CoV infection but not necessarily related to the severity of the disease (33). Here, HLA-DRB1 is linked to severe acute respiratory syndrome.