However, these are exceptional cases, while most PNH patients do not carry oncogenic mutations and most non-PIGA, non-HLA mutations in AA and PNH patients mirror age-related clonal hematopoiesis (e.g., DNMT3A, TET2, ASXL1, BCOR/BCORL1) (120, 124–127). Here, DNMT3A is linked to paroxysmal nocturnal hemoglobinuria.