PRDM1 and systemic lupus erythematosus: PRDM1 risk alleles have also been associated with systemic lupus erythematosus (SLE), and females carrying the rs548234 PRDM1 SNP, located at position 106120159 on chromosome 6, display a reduction in PRDM1 expression in monocyte-derived dendritic cells (Mo-DCs) but not B cells in the peripheral blood (85).