PRDM1 and ulcerative colitis: PRDM1-associated risk alleles have been linked with ulcerative colitis and Crohn’s disease through a comprehensive meta-analysis of six genome-wide association studies (GWAS) on ulcerative colitis patients, and another study identified one particular SNP, Ser354Asn, located at position 106659789 on chromosome 6, is associated with decreased plasmablasts, increased T cell proliferation and increased IFN-γ production (83, 84).