PRDM1 and viral infectious disease: Another study showed Blimp1 to be dispensable for the generation of CD8+ memory but essential for effective CD8+ T cell responses to viral infection, as both naïve and Influenza-primed Blimp1-deficient cells (using the fetal liver RAG blastocyst complementation system described above) exhibit stunted production of Granzyme B and effector differentiation in response to HKx31 viral infection (34).