In addition, another mucus-dwelling bacterium, Mucispirillum schaedleri, increased in both the colon and distal ileum mucosa of the Atg16L1T300A/T300A mice, was also reported by Caruso et al., which can trigger Nod2−/–&Cybb−/− (double–KO) mice developing spontaneous colitis (35). This evidence concerns the gene CYBB and colitis.