ARF6 and Familial prostate cancer: The human orthologue SMAP1 in the 6q13 region - association with aplastic anemia (62); tumor suppressor gene: prostate cancer (63), acute myeloid leukemia (64), and colon cancer (65). Also associated with pediatric venous thromboembolism (66). Via ARF6 - regulation of cancer cell invasion and metastasis, as well as tumor angiogenesis and growth (67, 68).