IL4R and infection: Interestingly, the route or site of infection has been shown to significantly influence the outcome of CL (80, 81), thus it will be interesting to decipher the phenotype exhibited following an intradermal infection with L. mexicana. Surprisingly, Type 2 immune responses, in the absence of IL-4Rα signaling on DCs, do increase substantially, yet disease outcome remains similar compared to littermate control.