ADCY1 and pertussis: Bordetella parapertussis also generates whooping cough (Watanabe and Nagai, 2004; Bouchez and Guiso, 2015) and produce an adenylate cyclase enzyme, CyaA, that is released to the extracellular medium and inhibits the ROS production generated by NOX (Gorgojo et al., 2017), inhibiting the NET induction in human-derived neutrophils (Figure 1).