A higher proportion of those treated with denosumab had hyperthyroidism (5.10% versus 3.08%, RR 1.66 [95% CI 1.11–2.48]), and they were more frequently users of insulin (22.65% versus 18.69%, RR 1.21 [95% CI 1.02–1.44]), opioids (84.29% versus 76.83%, RR 1.10 [95% CI 1.05–1.14]), and anxiolytics (92.86% versus 88.26%, RR 1.05 [95% CI 1.03–1.08]) compared to the alendronate group. Here, INS is linked to hyperthyroidism.