MTOR and metabolic dysfunction-associated steatohepatitis: In addition, 8-hydroxydeoxyguanosine, L-arginine and glucose metabolites were found to be upregulated in MetS and non-alcoholic steatohepatitis-associated hepatocarcinogenesis, and might take part in various tumor-associated processes, including the activation of oxidative stress resistance, mTOR pathways and cell proliferation (43).