FGFR3 and arthritic joint disease: FGFR3 deficiency in myeloid cells results in more severe joint destruction and synovitis in the destabilization of the medial meniscus (DMM)-induced mouse OA model and in aging mice, whilst blocking CXCR7 in FGFR3 deficiency mice relieved joint destruction of age-related/DMM-induced arthritis (59).