Alleviating tumor compression on the pituitary gland and stalk, removing mammosomatotroph or mixed somatotroph-lactotroph tumors, and lowering GH and IGF-1 levels after surgery may be possible mechanisms that result in the recovery of hypopituitarism and hyperprolactinemia (6, 20, 21, 23, 24). Here, IGF1 is linked to hypopituitarism.