Also, antibodies against epitempin disrupting the LGI1-ADAM22 complex cause a rare form of autoimmune encephalitis, characterized in some cases by peculiar faciobrachial dystonic seizures (FBDS) preceding the full-fledged clinical picture of cognitive dysfunction, memory impairment, and, eventually, tonic-clonic seizures. This evidence concerns the gene LGI1 and autoimmune encephalitis.