CRP and psychiatric disorder: A transdiagnostic meta-analysis (i.e., a meta-analysis conducted across diagnostic criteria for multiple stress-related psychiatric disorders) of the relationship between biological signatures of inflammation and stress-related psychiatric disorders revealed that, across k = 36 independent samples and n = 14,991 participants, trauma exposure was positively associated with plasma or serum concentrations of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α (68).