Two facts should be discussed regarding glycine-receptor antibody-associated cognitive impairment: first, in the hippocampus it is not mainly glycine-receptor subtype 1alpha, but rather alpha 2 and alpha 3 that are expressed in hippocampal tissue (13, 19), which may weaken the presumption that glycine-receptor autoimmunity is involved in cognitive impairment in our patients, as they presented glycine 1alpha-receptor autoantibodies. This evidence concerns the gene GLRA1 and Autoimmunity.