SLC5A2 and diabetes mellitus: Moreover, the model predicts that SGLT2 inhibition while lowering Na+ and glucose transport, significantly increases luminal [Cl–] at the macula densa (Figure 7), which may then attenuate glomerular hyperfiltration via tubuloglomerular feedback, consistent with clinical data, which show a reduction in eGFR in patients with diabetes following chronic SGLT2 inhibition.