Compared to healthy individuals, most cyto- and mt-aaRSs were downregulated in clinical samples from BALF and post-mortem lung tissues of patients with COVID-19, and the same holds true in SARS-CoV-2-infected human bronchial epithelial (NHBE) cells and A549-ACE2 cells compared to control cells (Figure 2 and Supplementary Table 3). This evidence concerns the gene ACE2 and COVID-19.