LEP and obesity due to melanocortin 4 receptor deficiency: The caloric imbalance observed in obesity is thought to be promoted by the development of leptin resistance and is also considered to be one of the primary risk factors for both overweight and obese individuals (Myers et al., 2008, 2010; Morris et al., 2010; Crujeiras et al., 2015; Cui et al., 2017; Engin, 2017; Liu et al., 2018).