Dexmedetomidine, a α2-adrenergic receptor (α2-AR) agonist, reduces myocardial iron concentration by reducing sepsis induced Hmox-1 overexpression, decreases inflammatory cytokines IL6 and MCP-1 expression, and increased GPX4 activity to reduce cardiac injury (Wang et al., 2020d). This evidence concerns the gene GPX4 and Sepsis.