In the model of myocardial infarction, macrophage polarization is affected by many regulators, such as collapsin response mediator protein-2 (CRMP-2), IRF5, and voltage-gated sodium Channels (VGSC) can induce M1 polarization, while Dendritic cells (DCs), mesenchymal stromal cells (MSCs), T regulatory cells (Tregs), fibroblast growth factor-9 (FGF-9) and colony stimulating factor receptor 1 (CFS-1R) can promote M2 polarization (Cheng and Rong, 2018). Here, DPYSL2 is linked to myocardial infarction.