Previously, Dixon et al. have shown that in HT-1080 fibrosarcoma cells, RSL3 can directly target GPX4 to inhibit its function, and erastin can directly inhibit the system xc- to reduce the uptake of cystine, and inactivate GPX4 by affecting the synthesis of the necessary cofactor GSH (Yang et al., 2014), leading to alleviate the ability of GPX4 to remove lipid peroxide. The gene discussed is GPX4; the disease is fibrosarcoma.