IL6 and plasma cell myeloma: Similarly, baicalein not only inhibited myeloma cell proliferation and induced apoptosis through downregulating IL-6 (Ma et al., 2005), but also abrogated IL-6-mediated signaling cascades including JAK, STAT3, MAPK, and Akt pathways associated with the proliferation and survival of MM cells (Liu et al., 2010).