In a study by Qing et al.(Qing et al., 2014), berberine decreased the p53 DNA CpG methylation level via suppressing DNA methyltransferases DNMT1 and DNMT3B, and affected mRNA levels of several primary apoptosis-related proteins, thus inducing apoptosis and cell cycle arrest in U266 MM cells. The gene discussed is TP53; the disease is Miyoshi myopathy.