Recently, An et al. (2020) and Ge et al. (2021) reported that PUN can ameliorate diabetic nephropathy and collagen-induced arthritis by attenuating nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing protein 3 (NLRP3)/caspase-1/gasdermin D (GSDMD)-mediated pyroptosis, respectively. This evidence concerns the gene GSDMD and diabetic kidney disease.