Firstly, severe COVID-19 is associated with a systemic hyper-inflammation state with increased cytokine levels and highly elevated C-reactive protein (CRP) all of which are known to impact drug PK through the downregulation of CYP isoenzymes (Dickmann et al., 2011; Simon et al., 2019; Simon et al., 2021). The gene discussed is PPIG; the disease is COVID-19.