Premature ovarian failure (POF), the current term for ovarian dysfunction called premature ovarian insufficiency (POI), occurs in women under 40 years of age whose follicle-stimulating hormone (FSH) level is > 40 IU/ml and is accompanied by secondary amenorrhea, infertility and low estrogen symptoms (Perry et al., 2013; Hewlett and Mahalingaiah, 2015). This evidence concerns the gene BRD2 and premature menopause.