Previous studies have confirmed that single nucleotide polymorphism of NOD1 affects the occurring and advancement of various tumors, comprising lung carcinoma, stomach carcinoma, colorectal carcinoma, pancreatic carcinoma, head and neck squamous cellular carcinoma, etc (Cotterchio et al., 2015; Ozbayer et al., 2015; Suarez et al., 2015). Here, NOD1 is linked to colorectal carcinoma.