The overexpression of vasodilator-stimulated phosphoprotein (VASP) and fibronectin (FN) is related to the poor prognosis of breast cancer, BBR not only binds to VASP to induce changes in its secondary structure but also decreases the expression of FN to inhibit cell proliferation and migration (Su et al., 2016; Jeong et al., 2018). The gene discussed is FN1; the disease is breast carcinoma.