PHLPP2 and neoplasm: The pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2), a tumor suppressor gene, can upregulate PHLPP2 from the PHLPP2-AKT-mammalian sterile 20-like kinase 1 (MST1) axis, exerting anti-proliferative effects (Saxena et al., 2018).