Moreover, LXA4 potently alleviated radicular pain in a rat model of noncompressive lumbar disc herniation by attenuating the activation of NF-κB/p65, p-ERK and p-JNK, but not p-p38, in the dorsal root ganglion (Miao et al., 2015). The gene discussed is MAPK1; the disease is lumbar disc herniation.