In a murine model of chronic asthma, we observed that metformin efficiently reduced infiltration of eosinophils and neutrophils, and production of Th2 cytokines and OVA-specific IgE, which partly fall in line with previous studies in obese or acute asthma models (Guo et al., 2021; Ma et al., 2021). The gene discussed is IGHE; the disease is chronic asthma.